Myelodysplasia (MDS)


Myelodysplasia (MDS)

Symptoms

Myelodysplasia (MDS) rarely causes symptoms in the early stage. However, the patient might notice these signs or symptoms:

  • Fatigue
  • Bleeding can result in pen-sized dot red spots just beneath your skin. This is also known as petechiae.
  • Shortness of breath
  • Paleness. This is due to anemia i.e. low red blood cell count.
  • Bruising or bleeding. This is due to thrombocytopenia i.e. low blood platelet count 
  • Frequent infections (Due to a low white blood cell count (leukopenia)).

When should I seek medical help?

You need to visit the best hospital for MDS treatment right away if the symptoms worry you or they are going away for a long time.

Causes

In a healthy person, the bone marrow can make new blood cells which are immature. With time, they get mature. If this process is affected then the Myelodysplastic syndromes occur which does not allow the cells to get mature. 

They do not develop normally, instead, they die before entering the bloodstream or in the bone marrow. With time, the number of defective cells increases which leads to the problem of fatigue caused by anemia, bleeding, and infection. 

In some cases, the problem does not result in any cause. Like, it can occur due to cancer treatment such as radiation or chemotherapy or use is toxic chemicals like pesticides, heavy metals (lead), benzene, or tobacco.

Tests

To give you the best Myelodysplasia (MDS) Treatment our doctor will do different tests to diagnose and determine the type of MDS.

  • Complete blood count (CBC):
    CBC blood test shows the blood cell number of each type. If you have MDS one or more types will be low.
  • Peripheral blood smear
    This test helps to determine the blood cell percentage of each type as well as if any of cell have dysplastic. To do this test, your blood is taken, one drop is put on the slide to examine it under the microscope.
  • Bone marrow aspiration and biopsy
    In this test, a hollow needle is put into the breastbone or hip centre. From the bone marrow, the liquid is taken out and tissue samples are removed. The sample helps to determine the blood cell percentage, blasts percentage, and if the bone marrow has abnormal cells. To confirm whether you have MDS, a bone marrow biopsy is needed.
  • Cytogenetic analysis
    For this test, blood or bone marrow samples are taken to look for changes or deletions in the chromosomes.

Diagnosis

In some cases, the person might have symptoms that indicate MDS. The doctor will do a complete physical examination, know your medical history, focus on the symptoms, and how the problem started. The doctor will examine you to determine the possible causes of the symptoms you have. 

Additionally, the above test will be done and their results can also tell the exact reason you have the problem. According to your condition, our doctor will give you the appropriate and effective treatment plan which will also determine the Myelodysplasia (MDS) Treatment cost.

 

Treatments

Myelodysplastic Syndrome (MDS) Treatment focuses on slowing down and managing the symptoms and disease progression. Well, the research on this disease is still going on.

Blood transfusions

Blood transfusions are used to replace white blood cells, red blood cells, or platelets in people with MDS.

Medications

Treatment for MDS might include medications for:

  • Increase the number of blood cells. The medications have artificial versions of substances found in the bone marrow. These medications are known to be growth factors, such as , filgrastim (Neupogen), epoetin alfa (Procrit), or darbepoetin alfa (Aranesp)
  • Stimulate blood cells to mature. Example: Decitabine (Dacogen), and Azacitidine (Vidaza) might improve the condition to reduce the condition of acute myelogenous leukemia.
  • If you have infections, you will be prescribed antibiotics.

Bone marrow transplant

Bone marrow transplant is also known as stem cell transplant. In this treatment, strong chemotherapy medications are used to remove the defective blood cells from the bone marrow. Healthy and donated cells are replaced with abnormal bone marrow stem cells.